Heart Regeneration: Lessons from Development
Walter and Eliza Hall Institute
1g Royal Parade
The adult mammalian heart has an extremely limited capacity for regeneration, which represents a fundamental barrier in cardiovascular medicine. A severe heart attack (myocardial infarction) can wipe out up to a billion cardiomyocytes in the space of just a few hours. In the absence of an appreciable regenerative response, the damaged heart muscle is replaced with a fibrotic scar tissue, which diminishes the heart’s capacity to pump blood around the body. There is currently intensive interest in developing strategies that can repopulate cardiomyocytes following ischaemic injury to prevent, delay or even reverse heart failure. A number of different approaches to heart regeneration are currently being developed including cellular therapies, cellular reprogramming (direct conversion of fibroblasts into cardiomyocytes) and stimulating endogenous regeneration via induction of cardiomyocyte proliferation. The scientific foundations for all of these regenerative approaches are grounded in a deep understanding of cardiac developmental biology.
This lecture will provide an up-to-date overview of contemporary approaches in cardiac regenerative medicine, which has the potential to transform the lives of heart failure patients.
No registration is required.
Associate Professor Enzo Porrello, Murdoch Children’s Research Institute
Associate Professor Enzo Porrello
Murdoch Children’s Research Institute
A/Professor Enzo Porello is Group Leader Cell Biology, Cardiac Regeneration at the Murdoch Children’s Research Institute; Dept of Physiology, School of Biomedical Sciences, The University of Melbourne